Key result
During incubation of arachidonic acid with platelet-rich plasma, a persistent release-inducing activity appeared that was identified as thromboxane A2, which persists in plasma with a half-life of 5 to 6 minutes at 37°C.
Population
Human blood platelets from volunteers who denied taking any drug within the previous week
Comparison
Incubation of arachidonic acid with… vs Incubation of arachidonic acid with…
Design
Preclinical
Authors
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TXA2 stability enables sustained platelet effects in vitro; leaves open its role and targeting in human thrombosis.
Plasma stabilizes thromboxane A2, prolonging its half-life and allowing for persistent platelet release-inducing activity, which provides insight into the biochemical mechanisms of platelet aggregation.
Smith et al. (1976) studied Healthy volunteers. Arachidonic acid incubation with platelet-rich plasma vs. Platelet-poor plasma or buffered saline was evaluated on Appearance and disappearance of 5-hydroxytryptamine-releasing activity and thromboxane A2-like material. During incubation of arachidonic acid with platelet-rich plasma, a persistent release-inducing activity appeared that was identified as thromboxane A2, which persists in plasma with a half-life of 5 to 6 minutes at 37°C.
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