Key result
Long-term oestrogen therapy was associated with significantly reduced carotid intima-medial thickness and improved systemic arterial compliance compared to no HRT.
Why the study?
Does long-term hormone replacement therapy with oestrogen or oestrogen plus progestin improve carotid IMT and arterial compliance in postmenopausal women compared to no HRT?
Population
241 participants including 60 older men, 90 postmenopausal women taking hormone replacement therapy, and 91…
Comparison
Long-term hormone replacement therapy with… vs Postmenopausal women not on HRT and older men
Design
Cross-sectional
Authors
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Supports vascular benefits of long-term estrogen; leaves open progestin effects and need for outcome trials before practice change.
Observational (n=241)
Does long-term hormone replacement therapy with oestrogen or oestrogen plus progestin improve carotid IMT and arterial compliance in postmenopausal women compared to no HRT?
Long-term estrogen therapy appears to protect against age-related increases in carotid IMT and arterial stiffness, though the addition of progestin may adversely influence arterial stiffness.
Liang et al. (1997) conducted an observational in Postmenopausal state and age-related arterial changes (n=241). Hormone replacement therapy (oestrogen alone or oestrogen plus progestin) vs. No hormone replacement therapy (and older men) was evaluated on Carotid artery intima-medial thickness (IMT) and indices of systemic and carotid arterial compliance. Long-term oestrogen therapy was associated with significantly reduced carotid intima-medial thickness and improved systemic arterial compliance compared to no HRT.
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