Key result
n-Alkanols inhibited Shaw2 whole-cell currents through a discrete saturable site, likely a hydrophobic pocket within the ion channel protein.
Population
Cloned K+ channels encoded by Drosophila Shaw2 and human Kv3.4
Design
Preclinical
Authors
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Offers mechanistic clues for anesthetic action on K+ channels; leaves open clinical relevance from this animal model.
Alcohols inhibit cloned potassium channels via a discrete hydrophobic site, providing insight into the molecular basis of general anesthetic action.
Covarrubias et al. (1995) studied this question. n-alkanols (ethanol to 1-hexanol) was evaluated on Inhibition of Shaw2 whole-cell currents and single channel openings. n-Alkanols inhibited Shaw2 whole-cell currents through a discrete saturable site, likely a hydrophobic pocket within the ion channel protein.
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