June 1, 1991The Journal of PhysiologyOpen Access

Actions of n‐alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes.

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Population

Inside-out membrane patches isolated from cultured rat myotubes

Design

Preclinical

Authors

RMRuth D. Murrell‐LagnadoUniversity of Sussex MBM. BraunUniversity of Alberta DHD.A. HaydonUniversity of Cambridge

Discussion

Member takes

Implication

n-Alcohols inhibit muscle nAChR currents via open-channel block in rat myotubes; leaves open relevance to human neuromuscular function or in vivo alcohol effects.

Structured PICO

Population

Inside-out membrane patches isolated from cultured rat myotubes

Intervention

n-alcohols from pentanol to dodecanol (aqueous concentrations 11.7 mM to 0.02 mM) applied to the cytoplasmic side of the membrane

Outcome

Single ACh-activated channel activity (channel currents, burst duration, gap duration, current integral per burst)surrogate

n-alcohols from pentanol to undecanol reduce the current integral per burst of nicotinic acetylcholine receptor channels in cultured rat myotubes, consistent with an open channel block model.

Cite This Study

Murrell‐Lagnado et al. (1991) studied this question.

synapsesocial.com/papers/6a853eec8918e6e2679290c7 https://doi.org/10.1113/jphysiol.1991.sp018604

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Implication

n-Alcohols inhibit muscle nAChR currents via open-channel block in rat myotubes; leaves open relevance to human neuromuscular function or in vivo alcohol effects.

Actions of n‐alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Actions of n‐alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider