Key result
Clinically relevant ethanol concentrations (10-20 mM) decreased the open probability of bovine aortic smooth muscle maxi-K channels by 75 +/- 20.3%.
Why the study?
Does ethanol alter the single-channel kinetics of bovine aortic smooth muscle maxi-K channels?
Population
bovine aortic smooth muscle maxi-K channels reconstituted in lipid bilayers
Design
Preclinical
Authors
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May link ethanol to vascular tone changes in animals; leaves open human arterial relevance.
Does ethanol alter the single-channel kinetics of bovine aortic smooth muscle maxi-K channels?
Clinically relevant concentrations of ethanol potently inhibit aortic smooth muscle maxi-K channels, suggesting a mechanism by which alcohol consumption may alter arterial tone.
Walters et al. (2000) studied Bovine aortic smooth muscle maxi-K channels. Ethanol was evaluated on Channel open probability (P(o)). Clinically relevant ethanol concentrations (10-20 mM) decreased the open probability of bovine aortic smooth muscle maxi-K channels by 75 +/- 20.3%.
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