Key result
Computational cardiology and cardiac modeling are advancing the optimization of existing therapies for cardiac arrhythmias and pump dysfunction, suggesting novel treatments, and aiding in diagnostics.
Cardiac modeling offers a promising approach to optimize existing therapies like defibrillation and CRT, and to discover novel molecular targets for cardiac disease.
Hypothesis-generating for arrhythmia and HF care; prospective trials needed before clinical adoption.
This paper reviews the newest developments in computational cardiology. It focuses on the contribution of cardiac modeling to the development of new therapies as well as the advancement of existing ones for cardiac arrhythmias and pump dysfunction. Reviewed are cardiac modeling efforts aimed at advancing and optimizing existent therapies for cardiac disease (defibrillation, ablation of ventricular tachycardia, and cardiac resynchronization therapy) and at suggesting novel treatments, including novel molecular targets, as well as efforts to use cardiac models in stratification of patients likely to benefit from a given therapy, and the use of models in diagnostic procedures.
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Natalia A. Trayanova (2012) conducted a review in Cardiac arrhythmias and pump dysfunction. Computational cardiology and cardiac modeling was evaluated. Computational cardiology and cardiac modeling are advancing the optimization of existing therapies for cardiac arrhythmias and pump dysfunction, suggesting novel treatments, and aiding in diagnostics.
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