Key result
Ketanserin provided comparable antihypertensive efficacy to dihydralazine but induced only minor changes in cardiac output, whereas dihydralazine significantly increased cardiac output (P<0.01).
Why the study?
Does ketanserin improve haemodynamic profiles compared to dihydralazine in pregnant women with severe early-onset hypertension?
Population
31 pregnant women with severe early-onset hypertension
Comparison
Ketanserin vs Dihydralazine
Design
RCT, randomised
Authors
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Supports ketanserin over dihydralazine when hemodynamic stability matters in severe pregnancy hypertension; extends RCT data guiding vasodilator choice.
RCT (n=31)
randomised
Yes
Does ketanserin improve haemodynamic profiles compared to dihydralazine in pregnant women with severe early-onset hypertension?
Ketanserin provides comparable antihypertensive efficacy to dihydralazine in severe early-onset pregnancy hypertension but with a more stable haemodynamic profile, avoiding the marked tachycardia and increased cardiac output seen with dihydralazine.
Bolte et al. (1998) conducted an RCT in severe early-onset hypertension in pregnancy (n=31). ketanserin vs. dihydralazine was evaluated on haemodynamic effects (cardiac output, systemic vascular resistance, heart rate). Ketanserin provided comparable antihypertensive efficacy to dihydralazine but induced only minor changes in cardiac output, whereas dihydralazine significantly increased cardiac output (P<0.01).