Key result
Epoprostenol sodium had similar antihypertensive effects to dihydralazine but caused significantly less tachycardia (mean pulse rate change to 88.36 vs 102.68 beats/min; P=0.0024).
Why the study?
Does epoprostenol reduce blood pressure as effectively as dihydralazine in pregnant patients with severe hypertension?
Population
47 pregnant patients with acute hypertensive crises and diastolic blood pressures > 100 mmHg
Comparison
Epoprostenol infusion (n=22) vs Dihydralazine (n=25)
Design
RCT, Randomized (method not specified)
Follow-up
Acute (until stabilization)
Authors
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Epoprostenol offers a comparable option to dihydralazine for severe hypertension in pregnancy with less tachycardia; extends alternatives for acute management in this population.
RCT (n=47)
randomized
No
Does epoprostenol reduce blood pressure as effectively as dihydralazine in pregnant patients with severe hypertension?
Epoprostenol is as effective as dihydralazine for acute severe hypertension in pregnancy but causes significantly less tachycardia.
Moodley et al. (1992) conducted an RCT in acute hypertensive crises of pregnancy (n=47). Epoprostenol sodium vs. Dihydralazine was evaluated on A significant drop in high blood pressure (fall of 15 mmHg diastolic and 30 mmHg systolic blood pressure). Epoprostenol sodium had similar antihypertensive effects to dihydralazine but caused significantly less tachycardia (mean pulse rate change to 88.36 vs 102.68 beats/min; P=0.0024).
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