What question did this study set out to answer?

To evaluate the clinical frequency and etiological factors associated with male breast carcinoma, including endocrine abnormalities and underlying conditions.

January 23, 1965BMJOpen Access

Carcinoma of Male Breast in Association with the Klinefelter Syndrome

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Authors

AJAbigail JacksonDepartment of Virology SMS. MuldalKingston Health Sciences Centre COC. H. OckeyThe Christie Hospital

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Implication

Retrospective review reveals male breast cancer accounts for under one percent of cases in hospital registry, suggesting endocrine factors influence pathogenesis.

Key Points

To evaluate the clinical frequency and etiological factors associated with male breast carcinoma, including endocrine abnormalities and underlying conditions.
Retrospective hospital record review of 11,543 patients presenting with breast carcinoma between 1945 and 1959 at Christie Hospital and Holt Radium Institute in Manchester, UK.
Identified 110 cases in males, accounting for 0.95% of total breast carcinoma presentations (110 of 11,543) and approximately 0.2% of all male cancers.
Identified prior administration of therapeutic estrogen for prostatic carcinoma as a documented precursor exposure in observed male breast cancers.
Noted that associated gynecomastia is difficult to identify clinically because male breast carcinoma typically presents late in life when adiposity increases.

Cite This Study

Jackson et al. (1965) studied this question.

synapsesocial.com/papers/6aa0196e77ee8cd849d56326 https://doi.org/10.1136/bmj.1.5429.223

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Implication

Retrospective review reveals male breast cancer accounts for under one percent of cases in hospital registry, suggesting endocrine factors influence pathogenesis.

Carcinoma of Male Breast in Association with the Klinefelter Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Carcinoma of Male Breast in Association with the Klinefelter Syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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