Key result
Invasive human arterial smooth muscle cells exhibited differential expression of 47 genes by more than 1.5-fold compared to quiescent cells, primarily involving extracellular matrix and cell motility.
Population
Human arterial smooth muscle cells (haSMCs) in an in vitro Boyden chamber model
Comparison
Invasive (proliferating/migrating) phenotype vs Quiescent (nonproliferating) phenotype
Design
Preclinical
Authors
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Hypothesis-generating for extracellular matrix targets in vascular remodeling; leaves open human translation from animal models.
The study identified 47 genes differentially expressed between quiescent and invasive human arterial smooth muscle cells, highlighting the role of extracellular matrix and cell motility proteins in vascular remodeling.
Blindt et al. (2002) studied Cardiovascular disorders (arteriosclerosis, restenosis, transplant vessel disease). Invasive phenotype vs. Quiescent (nonproliferating) phenotype was evaluated on Differential gene expression. Invasive human arterial smooth muscle cells exhibited differential expression of 47 genes by more than 1.5-fold compared to quiescent cells, primarily involving extracellular matrix and cell motility.
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