Rate Constants for Hydrogen Atom Abstraction by α-Tocopheroxyl Radical from Lipid, Hydroperoxide and Ascorbic Acid

The rate constants for each reaction of α-tocopheroxyl radical with methyl linoleate, t-butyl hydroperoxide and ascorbic acid, and also the bimolecular reaction of α-tocopheroxyl radicals were measured by a stopped-flow ESR technique in order to understand the antioxidant action of α-tocopherol. It was suggested that α-tocopheroxyl radical is primarily reduced by ascorbic acid in vivo.