Key result
Benznidazole treatment in dogs with chronic T. cruzi infection temporarily suppressed parasitaemia and slightly reduced systolic cardiac function decline, but did not prevent cardiomyopathy.
Why the study?
Does benznidazole treatment improve cardiac systolic function and prevent cardiomyopathy in a canine model of chronic Chagas' disease?
Population
28 dogs in an experimental model of Trypanosoma cruzi infection, divided into 10 infected and treated, 10…
Comparison
Benznidazole treatment during the chronic phase… vs Infected but untreated dogs, and…
Design
Preclinical
Follow-up
12 months post-treatment
Authors
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Benznidazole does not prevent cardiomyopathy in chronic canine Chagas; leaves open its role in human disease and need for alternative therapies.
Does benznidazole treatment improve cardiac systolic function and prevent cardiomyopathy in a canine model of chronic Chagas' disease?
In a canine model of chronic Chagas' disease, benznidazole temporarily suppressed parasitemia and slightly reduced systolic dysfunction but did not prevent the development of cardiomyopathy.
Santos et al. (2012) studied Chronic canine Chagas' disease (n=28). Benznidazole vs. Untreated infected dogs and healthy dogs was evaluated on Trypanocidal efficacy and cardiac systolic function. Benznidazole treatment in dogs with chronic T. cruzi infection temporarily suppressed parasitaemia and slightly reduced systolic cardiac function decline, but did not prevent cardiomyopathy.
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