Key result
A newly developed high-resolution SPECT imaging system accurately quantified myocardial infarction area in rats, with results comparable to histologic assessment (21.1% vs 21.7%, p=0.45).
Why the study?
Does high-resolution SPECT imaging accurately quantify myocardial infarction area compared to histology in a rat model?
Population
15 male Wistar rats, 13 of which underwent experimental myocardial infarction by occlusion of the left…
Comparison
In vivo high-resolution single photon emission… vs In vitro histopathologic measurement of…
Design
Preclinical, Investigators quantifying image processing and histologic studies…
Follow-up
4 weeks
Authors
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Does not inform clinical MI imaging; leaves open further validation of high-resolution SPECT in rodent models.
Does high-resolution SPECT imaging accurately quantify myocardial infarction area compared to histology in a rat model?
Absolute Event Rate: 21.1% vs 21.7%
p-value: p=0.45
An adapted, low-cost high-resolution SPECT imaging system accurately quantifies myocardial infarction area in rats, showing excellent correlation with histological fibrosis.
Oliveira et al. (2013) studied Experimental myocardial infarction (n=15). High-resolution SPECT imaging vs. Histology was evaluated on Myocardial infarct area (% of left ventricular surface) (p=0.45). A newly developed high-resolution SPECT imaging system accurately quantified myocardial infarction area in rats, with results comparable to histologic assessment (21.1% vs 21.7%, p=0.45).
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