Key result
Chagas disease is an independent risk factor for ischemic stroke, while African trypanosomiasis causes ECG alterations in over 70% of patients but requires further study to assess stroke risk.
Chagas disease is an independent risk factor for ischemic stroke, often presenting as cardioembolism, while the stroke risk in African trypanosomiasis requires further epidemiological study.
Chagas patients warrant stroke risk evaluation; leaves open whether African trypanosomiasis ECG changes confer stroke risk.
American (Chagas disease) and African (sleeping sickness) trypanosomiasis are neglected tropical diseases and are a heavy burden in Latin America and Africa, respectively. Chagas disease is an independent risk factor for stroke. Apical aneurysm, heart failure and cardiac arrhythmias are associated with ischemic stroke in chagasic cardiomyopathy. Not all chagasic patients who suffer an ischemic stroke have a severe cardiomyopathy, and stroke may be the first manifestation of Chagas disease. Cardioembolism affecting the middle cerebral artery is the most common stroke subtype. Risk of recurrence is high and careful evaluation of recurrence risk should be addressed. Repolarization changes, low voltage and prolonged QT interval are common electrocardiography alterations in human African trypanosomiasis, and can be found in more than 70% of patients. Epidemiological studies are needed to asses the risk of stroke in African trypanosomiasis perimyocarditis.
No takes yet. Share an insight, caveat, or question.
Francisco Javier Carod-Artal (2010) conducted a review in Trypanosomiasis and ischemic stroke. Trypanosomiasis was evaluated. Chagas disease is an independent risk factor for ischemic stroke, while African trypanosomiasis causes ECG alterations in over 70% of patients but requires further study to assess stroke risk.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: