βIV-Spectrin in Cardiac Fibroblasts: Implications for Fibrosis and Therapeutic Targeting in Cardiac Diseases. Comment on Nassal et al. Spectrin-Based Regulation of Cardiac Fibroblast Cell-Cell Communication. Cells 2023, 12, 748

Figures

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  Figure 1. βIV-spectrin/CaMKII/STAT3 signalosome regulates fibroblast–fibroblast communication and fibrosis. The reduction in βIV-spectrin caused by ablation or CaMKII-mediated degradation promotes STAT3 translation into the nucleus. βIV-spectrin forms a complex with STAT3 and CaMKII, which directly phosphorylate βIV-spectrin. CaMKII: Calcium/calmodulin-dependent protein kinase II. STAT3: signal transducer and activator of transcription 3 (STAT3).

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  Figure 2. Dysregulation of βIV-spectrin in heart failure with preserved ejection fraction (HFpEF) (GSE3586).