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Investigate the chemical addition of hydrogen cyanide across the conjugated system of chalcones to prepare beta-cyano ketone derivatives.

January 1, 1958Journal of the Chemical Society (Resumed)

Chalcones and related compounds. Part IV. Addition of hydrogen cyanide to chalcones

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Investigate the chemical addition of hydrogen cyanide across the conjugated system of chalcones to prepare beta-cyano ketone derivatives.
Subjected various substituted chalcones to reaction with hydrogen cyanide under controlled synthetic conditions.
Isolated and structurally characterized the resulting hydrocyanation adducts.
Addition of hydrogen cyanide across the alpha,beta-unsaturated ketone system consistently formed the corresponding beta-cyano ketones.
Demonstrated the general synthetic utility and regioselectivity of hydrocyanation on diverse chalcone analogs.

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Implication

Chemical synthesis study demonstrates nucleophilic addition of hydrogen cyanide to chalcones, highlighting synthetic routes to functionalized beta-cyano ketones.

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Cite This Study

Davey et al. (1958) studied this question.

synapsesocial.com/papers/6aa02038dd133cd5dbe62410 https://doi.org/10.1039/jr9580001230

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Implication

Chemical synthesis study demonstrates nucleophilic addition of hydrogen cyanide to chalcones, highlighting synthetic routes to functionalized beta-cyano ketones.

Chalcones and related compounds. Part IV. Addition of hydrogen cyanide to chalcones

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Implication

Discussion

Cite This Study

Chalcones and related compounds. Part IV. Addition of hydrogen cyanide to chalcones

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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