Key result
Both (R)- and (S)-propafenone (10 microM) shifted the membrane potential required for half-maximal steady-state inactivation of the cardiac sodium channel to more negative potentials than controls.
Why the study?
Does (R)- and (S)-propafenone stereoselectively interact with the cardiac sodium channel in guinea pig ventricular cells?
Does (R)- and (S)-propafenone stereoselectively interact with the cardiac sodium channel in guinea pig ventricular cells?
(S)-propafenone is more effective than (R)-propafenone in shifting the steady-state inactivation curve of the cardiac sodium channel to more negative potentials in guinea pig ventricular cells.
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Animal data indicate stereoselective sodium channel effects; leaves open any clinical relevance in humans.
Schreibmayer et al. (1992) studied this question. (R)- and (S)-propafenone vs. controls was evaluated on membrane potential required for half-maximal steady-state inactivation (E0.5) of the cardiac sodium channel. Both (R)- and (S)-propafenone (10 microM) shifted the membrane potential required for half-maximal steady-state inactivation of the cardiac sodium channel to more negative potentials than controls.
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