Key result
Propofol blocked whole-cell sodium currents in rat ventricular myocytes, with potency dependent on holding potential (EC50 2.8 µg/mL at -90 mV vs 44.0 µg/mL at -140 mV).
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Does not alter propofol use in anesthesia; leaves open human cardiac sodium channel relevance.
Saint et al. (1998) studied this question. Propofol was evaluated on Cardiac whole-cell sodium currents and single sodium channels. Propofol blocked whole-cell sodium currents in rat ventricular myocytes, with potency dependent on holding potential (EC50 2.8 µg/mL at -90 mV vs 44.0 µg/mL at -140 mV).
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