Why the study?
Does propofol affect cardiac conduction and ionic currents in rabbit hearts?
Population
Langendorff-perfused rabbit hearts and isolated rabbit atrial and ventricular myocytes
Design
Preclinical
Authors
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May suppress AV conduction via ion channel blockade in rabbits; leaves open clinical relevance in humans.
Does propofol affect cardiac conduction and ionic currents in rabbit hearts?
Propofol exerts direct dromotropic and chronotropic effects on the cardiac conduction system, primarily by suppressing cardiac ICa, INa, and Ito currents.
Wu et al. (1997) studied this question.
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