Why the study?
Does propofol reduce the firing rate and alter ionic currents in isolated guinea pig sinoatrial node cells?
Population
Sinoatrial node cells isolated from guinea pig hearts and Langendorff-perfused isolated guinea pig hearts
Design
Preclinical
Authors
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May explain propofol bradycardia via SAN ion channel effects in guinea pigs; leaves open human translation.
Does propofol reduce the firing rate and alter ionic currents in isolated guinea pig sinoatrial node cells?
Propofol induces bradycardia through direct multiple channel inhibition (If, ICa,T, ICa,L, IKs) in sinoatrial node cells.
Kojima et al. (2014) studied this question.
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