Why the study?
Does propofol inhibit Ca2+ transients and left ventricular pressure in intact beating guinea pig hearts?
Does propofol inhibit Ca2+ transients and left ventricular pressure in intact beating guinea pig hearts?
Propofol decreases intracellular Ca2+ transients without reducing cardiac contraction in intact guinea pig hearts, likely by impairing sarcoplasmic reticulum Ca2+ handling while enhancing myofilament Ca2+ sensitivity.
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May not alter propofol use in patients; leaves open whether enhanced myofilament Ca2+ sensitivity occurs in human hearts.
Nakae et al. (2000) studied this question.
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