Why the study?
Does propofol alter contractile response and electrophysiological properties in guinea-pig ventricular myocytes?
Population
Guinea-pig single cardiac myocytes (n=5)
Comparison
Propofol (10(-5) M and 10(-4) M) vs Control
Design
Preclinical
Authors
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Hypothesis-generating for propofol's cardiac effects in animals; leaves open translation to human myocardium.
Does propofol alter contractile response and electrophysiological properties in guinea-pig ventricular myocytes?
Propofol exerts a negative inotropic effect in guinea-pig ventricular myocytes by suppressing the action potential and inhibiting L-type calcium channels.
Shigemura et al. (1999) studied this question.
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