Key result
In isolated guinea pig hearts, propofol slowed atrial rate and depressed AV nodal conduction in a concentration- and frequency-dependent manner, predominantly mediated by M2-muscarinic receptors.
Why the study?
Does propofol affect atrioventricular nodal conduction in guinea pig isolated hearts?
Population
Guinea pig isolated, perfused hearts
Design
Preclinical
Authors
Loading...
May caution propofol use during rapid atrial rates; leaves open M2-mediated translation to human AV conduction.
Does propofol affect atrioventricular nodal conduction in guinea pig isolated hearts?
Propofol slows atrial rate and depresses AV nodal conduction in isolated guinea pig hearts via a frequency-dependent, M2-muscarinic receptor-mediated mechanism.
Alphin et al. (1995) studied this question. Propofol was evaluated on Atrial rate, AV nodal conduction time, and stimulus-to-His bundle intervals. In isolated guinea pig hearts, propofol slowed atrial rate and depressed AV nodal conduction in a concentration- and frequency-dependent manner, predominantly mediated by M2-muscarinic receptors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: