Why the study?
Does propofol have age-related effects on the electrophysiological properties of isolated neonatal and adult rabbit hearts?
Population
Isolated hearts from neonatal and adult rabbits in Langendorff-perfusion with autonomic blockade
Comparison
Propofol at concentrations ranging from 3 microM… vs Adult vs neonatal hearts, and baseline…
Design
Preclinical
Authors
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Propofol's age-dependent AV effects in rabbits suggest neonatal vulnerability at high doses; leaves open human translation and pediatric dosing studies.
Does propofol have age-related effects on the electrophysiological properties of isolated neonatal and adult rabbit hearts?
Propofol exhibits age-dependent electrophysiological effects on isolated rabbit hearts, with higher concentrations causing complete AV block in neonates but not adults.
Wu et al. (1997) studied this question.
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