Why the study?
Does propofol alter electrophysiological parameters in the normal cardiac conduction system of pigs?
Population
10 closed-chest pigs weighing 20-25 kg, premedicated with intramuscular ketamine hydrochloride, intubated…
Comparison
Propofol at two doses: low dose and high dose vs Baseline values (prior to propofol administration)
Design
Preclinical
Authors
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Propofol may depress sinus node and His-Purkinje function in pigs; leaves open translation to clinical bradyarrhythmia risk.
Does propofol alter electrophysiological parameters in the normal cardiac conduction system of pigs?
Propofol causes dose-related depression of sinus node and His-Purkinje system functions in normal pig hearts, providing a potential mechanism for propofol-induced bradyarrhythmias.
Pires et al. (2008) studied this question.
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