Why the study?
Does propofol reduce myocyte contractile function in isolated swine myocytes with and without pacing-induced congestive heart failure?
Does propofol reduce myocyte contractile function in isolated swine myocytes with and without pacing-induced congestive heart failure?
Propofol has a direct negative inotropic effect on isolated ventricular myocytes, with failing myocytes exhibiting increased sensitivity at lower concentrations.
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May warrant caution with propofol in CHF; leaves open translation from isolated swine myocytes to humans.
Hebbar et al. (1997) studied this question.
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