Why the study?
Does propofol modify the inotropic and lusitropic responses to alpha- and beta-adrenoceptor stimulation in rat myocardium?
Population
Rat left ventricular papillary muscles in vitro
Comparison
Propofol (1 and 10 microg/mL) and its solvent vs Control groups
Design
Preclinical
Authors
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Propofol selectively abolishes alpha- but not beta-adrenoceptor inotropy in rat myocardium; leaves open human relevance and clinical translation.
Does propofol modify the inotropic and lusitropic responses to alpha- and beta-adrenoceptor stimulation in rat myocardium?
High concentrations of propofol abolish the positive inotropic effect of alpha-adrenoceptor stimulation but not beta-adrenoceptor stimulation in rat myocardium.
Lejay et al. (1998) studied this question.
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