Why the study?
Does propofol modify the inotropic response to alpha- and beta-adrenoceptor stimulation in rat myocardium?
Population
Rat left ventricular papillary muscles in vitro
Comparison
Propofol (1 and 10 µg/mL) and its solvent vs Control groups
Design
Preclinical
Authors
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No immediate change to propofol use with vasopressors warranted; leaves open translation of alpha- vs beta-adrenoceptor selectivity to human myocardium.
Does propofol modify the inotropic response to alpha- and beta-adrenoceptor stimulation in rat myocardium?
High concentrations of propofol abolish the positive inotropic effect of alpha-adrenoceptor stimulation but not beta-adrenoceptor stimulation in rat myocardium.
Lejay et al. (1998) studied this question.
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