Why the study?
Does propofol affect intrinsic myocardial contractility in isolated rat left ventricular papillary muscles?
Population
Isolated rat left ventricular papillary muscles
Comparison
Propofol at three concentrations vs Propofol solvent
Design
Preclinical
Authors
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Suggests limited direct myocardial effects in rat model; leaves open mechanisms of in vivo depression and human translation.
Does propofol affect intrinsic myocardial contractility in isolated rat left ventricular papillary muscles?
Propofol induces only moderate changes on intrinsic myocardial contractility in vitro, suggesting that in vivo cardiovascular depression is not related to intrinsic myocardial depression.
Riou et al. (1992) studied this question.
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