What question did this study set out to answer?

To determine whether sedative doses of propofol alter the electrophysiological properties of the atrioventricular node conduction system in patients with atrioventricular nodal reentrant tachycardia.

December 1, 2006Pacing and Clinical ElectrophysiologyOpen Access

Randomized Study of Propofol Effect On Electrophysiological Properties of the Atrioventricular Node in Patients with Nodal Reentrant Tachycardia

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Why the study?

Does propofol at sedative doses alter the electrophysiological properties of the AV node in patients with AVNRT undergoing ablation?

Population

Patients with atrioventricular nodal reentrant tachycardia (AVNRT) undergoing percutaneous catheter ablation

Comparison

Propofol at sedative doses vs Placebo

Design

RCT, Randomly assigned

Authors

PWPaulo WarpechowskiFundação Universitária de Cardiologia GLGustavo Glotz de LimaFundação Universitária de Cardiologia CMClaudio Meirelles MedeirosFundação Faculdade de Medicina

Discussion

Member takes

Implication

Supports propofol sedation in AVNRT ablation; confirms neutral AV nodal effects in this RCT.

Key Points

To determine whether sedative doses of propofol alter the electrophysiological properties of the atrioventricular node conduction system in patients with atrioventricular nodal reentrant tachycardia.
Randomized trial assigning patients with atrioventricular nodal reentrant tachycardia to receive either sedative doses of propofol or placebo during an electrophysiological study.
Electrophysiological testing evaluated anterograde and retrograde effective refractory periods of the fast pathway, the anterograde effective refractory period of the slow pathway, and cycle length alongside AH, HV, and VA conduction intervals.
Propofol induced no statistically significant alterations (P > 0.05) in the anterograde or retrograde effective refractory periods of the fast pathway or the anterograde effective refractory period of the slow pathway.
Atrial-His (AH), His-ventricular (HV), and ventriculoatrial (VA) conduction intervals remained unaffected, allowing sustained reciprocating tachycardia to be successfully induced and slow pathways ablated in all patients.

Structured PICO

Does propofol at sedative doses alter the electrophysiological properties of the AV node in patients with AVNRT undergoing ablation?

Population

Patients with atrioventricular nodal reentrant tachycardia (AVNRT) undergoing percutaneous catheter ablation

Intervention

Propofol at sedative doses

Comparator

Placebo

Outcome

Electrophysiological properties of the atrioventricular (AV) node conduction system (anterograde and retrograde effective refractory periods of the fast pathway, anterograde effective refractory period of the slow pathway, cycle length, and AH, HV, and VA intervals)surrogate

Propofol at sedative doses does not alter AV node electrophysiological properties, making it a suitable anesthetic agent for patients undergoing AVNRT ablation.

Cite This Study

Warpechowski et al. (2006) studied this question.

synapsesocial.com/papers/69f1a129e7adab9d6a2a7ccd https://doi.org/10.1111/j.1540-8159.2006.00550.x

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Randomized Study of Propofol Effect On Electrophysiological Properties of the Atrioventricular Node in Patients with Nodal Reentrant Tachycardia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Randomized Study of Propofol Effect On Electrophysiological Properties of the Atrioventricular Node in Patients with Nodal Reentrant Tachycardia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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