What is the clinical evidence from this study?

Study design: Other. Population: recurrent paroxysmal supraventricular tachycardia (n=12). Intervention: Propafenone. Primary outcome: Interruption of tachycardia.

What question did this study set out to answer?

To evaluate the electrophysiological actions and antiarrhythmic efficacy of propafenone using programmed cardiac electrical stimulation in patients with recurrent paroxysmal supraventricular tachycardia.

August 1, 1981European Heart Journal

Electrophysiological effects of propafenone studied with programmed electrical stimulation of the heart in patients with recurrent paroxysmal supraventricular tachycardia

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Key result

Intravenous propafenone interrupted tachycardia in 10 of 11 patients during episodes, and lengthened transnodal conduction time and refractory periods.

Why the study?

Does propafenone alter electrophysiological properties and interrupt tachycardia in patients with recurrent paroxysmal supraventricular tachycardia?

Population

12 patients suffering from recurrent episodes of reentrant supraventricular tachycardia

Design

Case_series

Authors

AWA WaleffeUniversity of Liège LML Mary-RabineUniversity of Liège RRR. DE RUBELUniversity of Liège

Discussion

Member takes

Implication

May support acute PSVT termination in select cases; hypothesis-generating for electrophysiological effects, requiring controlled trials.

Key Points

To evaluate the electrophysiological actions and antiarrhythmic efficacy of propafenone using programmed cardiac electrical stimulation in patients with recurrent paroxysmal supraventricular tachycardia.
Performed programmed electrical heart stimulation in 12 patients with recurrent paroxysmal supraventricular tachycardia (5 with AV nodal tachycardia, 6 with circus movement tachycardia involving an accessory pathway, and 1 with atrial flutter/fibrillation with Wolff-Parkinson-White syndrome).
Administered intravenous propafenone at a dose of 2 mg/kg during electrophysiological evaluation, and assessed chronic oral therapy (300 mg three times daily) in 5 patients.
Intravenous propafenone prolonged transnodal conduction time, the HV interval, VA conduction time, and the refractory period of right atrial muscle.
Terminated acute tachycardia in 10 of 11 patients (91%), though ventricular premature beats initiated termination in 3 instances, and sustained tachycardia remained inducible in 6 of 12 patients post-treatment.
Prolonged accessory pathway refractory periods in 3 of 4 anterograde assessments (with 1 complete block) and in 4 of 6 retrograde assessments.

Structured PICO

Does propafenone alter electrophysiological properties and interrupt tachycardia in patients with recurrent paroxysmal supraventricular tachycardia?

Population

12 patients with recurrent episodes of reentrant supraventricular tachycardia evaluated for electrophysiological effects of propafenone.

Intervention

Propafenone perfused intravenously at a dose of 2 mg/kg over W min; chronic oral propafenone administration (300 mg t.d.s.) assessed in 5 patients

Outcome

Electrophysiological effects (transnodal conduction time, H V interval, VA conduction time, refractory period of right atrial muscle, effects on accessory pathways) and interruption of tachycardiasurrogate

Propafenone demonstrates effective electrophysiological properties for interrupting supraventricular tachycardia and may protect against high ventricular rates in preexcitation syndromes.

Cite This Study

Waleffe et al. (1981) studied recurrent paroxysmal supraventricular tachycardia (n=12). Propafenone was evaluated on Interruption of tachycardia. Intravenous propafenone interrupted tachycardia in 10 of 11 patients during episodes, and lengthened transnodal conduction time and refractory periods.

synapsesocial.com/papers/6a940445189c14fbc5b9485f https://doi.org/10.1093/oxfordjournals.eurheartj.a061215

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Electrophysiological effects of propafenone studied with programmed electrical stimulation of the heart in patients with recurrent paroxysmal supraventricular tachycardia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Electrophysiological effects of propafenone studied with programmed electrical stimulation of the heart in patients with recurrent paroxysmal supraventricular tachycardia

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider