October 1, 1988Circulation

Electrophysiological effects and clinical efficacy of propafenone in children with recurrent paroxysmal supraventricular tachycardia.

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Why the study?

Does propafenone alter electrophysiological properties and prevent tachycardia recurrences in children with recurrent paroxysmal supraventricular tachycardia?

Population

24 children with recurrent paroxysmal supraventricular tachycardia.

Design

Cohort

Follow-up

26 +/- 10 months

Authors

BMB MustoEastern Virginia Medical School ADAntonio D’OnofrioOak Ridge National Laboratory CCC. CavallaroAzienda di Rilievo Nazionale ed Alta Specializzazione

Discussion

Member takes

Implication

Propafenone was associated with high termination and prevention rates in pediatric PSVT; hypothesis-generating and should not yet change practice pending RCTs.

Structured PICO

Does propafenone alter electrophysiological properties and prevent tachycardia recurrences in children with recurrent paroxysmal supraventricular tachycardia?

Population

24 children (mean age 10.1 +/- 4.5 years) with recurrent paroxysmal supraventricular tachycardia (11 with overt accessory connection, 7 with concealed accessory connection, 6 with no accessory connection).

Intervention

Propafenone (acute administration during electrophysiological study followed by long-term oral therapy)

Outcome

Electrophysiological parameters (refractory periods, conduction intervals, tachycardia inducibility) and long-term prevention of tachycardia recurrencessurrogate

Propafenone is highly effective in terminating and preventing recurrences of paroxysmal supraventricular tachycardia in pediatric patients, with short-term EP testing predicting long-term oral efficacy.

Cite This Study

Musto et al. (1988) studied this question.

synapsesocial.com/papers/6a710daba2d7cf2e39c2bf78 https://doi.org/10.1161/01.cir.78.4.863

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Implication

Propafenone was associated with high termination and prevention rates in pediatric PSVT; hypothesis-generating and should not yet change practice pending RCTs.

Electrophysiological effects and clinical efficacy of propafenone in children with recurrent paroxysmal supraventricular tachycardia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrophysiological effects and clinical efficacy of propafenone in children with recurrent paroxysmal supraventricular tachycardia.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider