Key result
Propafenone reduces ambulatory arrhythmias and abolishes inducible VT in ~57% of patients with LV dysfunction.
Why the study?
Does propafenone reduce ventricular tachyarrhythmias in patients with impaired left ventricular function?
Does propafenone reduce ventricular tachyarrhythmias in patients with impaired left ventricular function?
In a small cohort, propafenone reduced ventricular tachyarrhythmias without significantly changing ejection fraction, though modern guidelines now strictly contraindicate Class IC antiarrhythmics in patients with structural heart disease or impaired LV function.
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Propafenone appeared to suppress arrhythmias without LVEF change in this small series; leaves open any role amid current Class IC contraindications in structural heart disease.
Brodsky et al. (1986) studied Ventricular tachyarrhythmias with impaired left ventricular function (n=15). Propafenone was evaluated on Ventricular arrhythmias on ambulatory monitoring. Propafenone significantly reduced ventricular arrhythmias on ambulatory monitoring and abolished inducible ventricular tachycardia in 4 of 7 patients with impaired left ventricular function.
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