Key result
Propafenone effectively suppresses chronic ventricular ectopic depolarizations and eliminates nonsustained ventricular tachycardia in most patients.
Why the study?
Does propafenone suppress chronic ventricular ectopic depolarizations?
Does propafenone suppress chronic ventricular ectopic depolarizations?
Propafenone is effective for suppressing chronic ventricular ectopic depolarizations, with its efficacy best predicted by PR and QRS interval prolongation rather than plasma levels.
May support propafenone for refractory ventricular ectopy; hypothesis-generating from Level 5 data and requires randomized confirmation.
Propafenone is an effective agent for suppression of chronic ventricular ectopic depolarizations. Complete elimination of nonsustained ventricular tachycardia is achieved in most patients treated with propafenone. The efficacy of propafenone is best correlated with its prolongation of the PR and QRS intervals whereas its plasma level is a poor predictor of therapeutic efficacy. Although serious side effects do occur with propafenone therapy and the drug must be discontinued in some patients, successful therapy of patients for up to four years has been reported.
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Salerno et al. (1986) conducted a review in Chronic ventricular ectopic depolarizations and nonsustained ventricular tachycardia. Propafenone was evaluated on Suppression of chronic ventricular ectopic depolarizations and elimination of nonsustained ventricular tachycardia. Propafenone effectively suppresses chronic ventricular ectopic depolarizations and eliminates nonsustained ventricular tachycardia in most patients.
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