Why the study?
Does propafenone cause malignant ventricular tachyarrhythmias in patients treated for chronic complex ventricular ectopic activity?
Population
5 patients with chronic complex ventricular ectopic activity, all receiving digoxin and low dose diuretic…
Design
Case_series
Follow-up
within the first three days of treatment
Authors
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Propafenone may trigger early proarrhythmia without QT prolongation; case reports leave open causality and require prospective confirmation.
Does propafenone cause malignant ventricular tachyarrhythmias in patients treated for chronic complex ventricular ectopic activity?
Propafenone can cause early, fatal proarrhythmic effects (malignant ventricular tachyarrhythmias) in patients treated for ventricular ectopic activity, even without marked QT prolongation.
Buss et al. (1985) studied this question.
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