Key result
Ketamine significantly increased heart rate (change 12.4 bpm) and systolic blood pressure (19.2 mmHg), and shortened atrial conduction time (-13.7 ms) compared to propofol and control.
Why the study?
Do propofol and ketamine affect atrial electrophysiology and hemodynamics in patients undergoing SVT ablation compared to midazolam alone?
Population
31 patients undergoing electrophysiological study prior to supraventricular tachycardia (SVT) ablation
Comparison
Propofol/midazolam or ketamine/midazolam vs Midazolam alone (n=12)
Design
Cohort
Authors
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May support ketamine in hypotensive SVT ablation patients; hypothesis-generating for effects on procedural outcomes.
Observational (n=31)
Do propofol and ketamine affect atrial electrophysiology and hemodynamics in patients undergoing SVT ablation compared to midazolam alone?
Absolute Event Rate: 12.4% vs 1%
p-value: p=0.002
Ketamine has stimulatory effects on heart rate, atrial conduction, and blood pressure during SVT ablation, suggesting it may be beneficial in patients with pre-existing hypotension and bradycardia.
Wutzler et al. (2013) conducted an observational in Supraventricular tachycardia (SVT) (n=31). Ketamine/midazolam or Propofol/midazolam vs. Midazolam alone was evaluated on Change in heart rate (b.p.m.) (p=0.002). Ketamine significantly increased heart rate (change 12.4 bpm) and systolic blood pressure (19.2 mmHg), and shortened atrial conduction time (-13.7 ms) compared to propofol and control.
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