Population
Rat myocardial membranes, intact rat cardiomyocytes, and isolated rat papillary muscle
Comparison
Propofol (concentrations as low as 6 microM) vs Etomidate and ketamine (in separate experiments)
Design
Preclinical
Authors
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May depress contractility via L-type Ca channel inhibition in animals; leaves open clinical relevance in human anesthesia.
Propofol depresses myocardial contractility by inhibiting cardiac L-type calcium currents through interaction with the dihydropyridine-binding site.
Zhou et al. (1997) studied this question.
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