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February 1, 2005Journal of Interventional Cardiology

Predictors of Bleeding Complications and Thrombocytopenia with the Use of Abciximab during Percutaneous Coronary Intervention

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Key result

Adjunctive use of abciximab during PCI resulted in major bleeding in 1.7% and thrombocytopenia in 3.9% of patients, with female gender and bail-out use identified as risk factors.

Why the study?

What are the clinical predictors of bleeding complications in patients receiving abciximab during PCI?

Population

344 consecutive patients who underwent percutaneous coronary intervention with adjunctive use of abciximab

Design

Cohort

Authors

OROmar Abdul RazakjrNational University of SingaporeHTHuay Cheem TanNational University of SingaporeWYWei Luen James YipNational University Heart Centre Singapore

Discussion

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Implication

May inform bleeding risk discussions for abciximab in PCI; hypothesis-generating for refined selection pending prospective validation.

Study Design

Type

Cohort (n=344)

Structured PICO

What are the clinical predictors of bleeding complications in patients receiving abciximab during PCI?

P
Population
344 consecutive patients undergoing percutaneous coronary intervention with adjunctive use of abciximab.
E
Exposure
Abciximab adjunctive to PCI
O
Outcome
Incidence of bleeding complications and identification of clinical predictorssafety

Female gender and bail-out use of abciximab are associated with an increased risk of bleeding complications during PCI.

Cite This Study

Razakjr et al. (2005) conducted a cohort in Percutaneous coronary intervention (n=344). Abciximab was evaluated on Major bleeding. Adjunctive use of abciximab during PCI resulted in major bleeding in 1.7% and thrombocytopenia in 3.9% of patients, with female gender and bail-out use identified as risk factors.

synapsesocial.com/papers/6aa0223cccefcc8ad0efdadchttps://doi.org/10.1111/j.1540-8183.2005.04031.x

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Importance of adequate heparin dosage in arterial angioplasty in a porcine model.1988 · 99 citations
  2. 2Bleeding Complications With the Chimeric Antibody to Platelet Glycoprotein IIb/IIIa Integrin in Patients Undergoing Percutaneous Coronary Intervention1995 · 242 citations
  3. 3Hemorrhagic Events during Therapy with Recombinant Tissue-Type Plasminogen Activator, Heparin, and Aspirin for Acute Myocardial Infarction1991 · 484 citations
  4. 4Platelet membrane activation markers are predictive for increased risk of acute ischemic events after PTCA.1993 · 206 citations