Key result
Black soybean seed coat extract ameliorated obesity and glucose intolerance in high-fat diet-fed mice by up-regulating uncoupling proteins and down-regulating inflammatory cytokines.
Why the study?
Does black soybean seed coat extract prevent obesity and glucose intolerance in high-fat diet-fed mice?
Does black soybean seed coat extract prevent obesity and glucose intolerance in high-fat diet-fed mice?
Black soybean seed coat extract ameliorates obesity and glucose intolerance in high-fat diet-fed mice by up-regulating uncoupling proteins and suppressing inflammation.
Does not support clinical use; hypothesis-generating for metabolic effects of black soybean extract in humans.
Black soybean seed coat extract (BE) is a polyphenol-rich food material consisting of 9.2% cyanidin 3-glucoside, 6.2% catechins, 39.8% procyanidins, and others. This study demonstrated that BE ameliorated obesity and glucose intolerance by up-regulating uncoupling proteins (UCPs) and down-regulating inflammatory cytokines in C57BL/6 mice fed a control or high-fat diet containing BE for 14 weeks. BE suppressed fat accumulation in mesenteric adipose tissue, reduced the plasma glucose level, and enhanced insulin sensitivity in the high-fat diet-fed mice. The gene and protein expression levels of UCP-1 in brown adipose tissue and UCP-2 in white adipose tissue were up-regulated by BE. Moreover, the gene expression levels of major inflammatory cytokines, tumor necrosis factor-α and monocyte chemoattractant protein-1 were remarkably decreased by BE in white adipose tissue. BE is a beneficial food material for the prevention of obesity and diabetes by enhancing energy expenditure and suppressing inflammation.
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Kanamoto et al. (2011) studied Obesity and glucose intolerance. Black soybean seed coat extract (BE) vs. Control or high-fat diet without BE was evaluated on Fat accumulation, plasma glucose level, insulin sensitivity, and gene/protein expression of UCPs and inflammatory cytokines. Black soybean seed coat extract ameliorated obesity and glucose intolerance in high-fat diet-fed mice by up-regulating uncoupling proteins and down-regulating inflammatory cytokines.
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