Key result
Warfarin was associated with the highest risk for 30-day and 90-day postoperative complications following total hip arthroplasty, including an increased risk of 30-day DVT (OR 1.53).
Why the study?
Do different VTE chemoprophylactic regimens have different rates of postoperative complications in patients undergoing total hip arthroplasty?
Population
72,670 total hip arthroplasty patients without a history of venous thromboembolism from a nationwide…
Comparison
VTE prophylaxis within 30 days postoperatively vs Other VTE chemoprophylactic regimens
Design
Cohort
Follow-up
90 days
Authors
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May inform VTE regimen selection after THA; leaves open optimal prophylaxis pending randomized trials.
Cohort (n=25,966)
Yes
Do different VTE chemoprophylactic regimens have different rates of postoperative complications in patients undergoing total hip arthroplasty?
Odds Ratio: 1.53 (95% CI 1.39–1.67)
p-value: p=<0.05
In patients undergoing total hip arthroplasty, enoxaparin and rivaroxaban appear to offer better safety and efficacy profiles for VTE prophylaxis compared to warfarin.
Agaba et al. (2017) conducted a cohort in Total hip arthroplasty (THA) (n=25,966). Warfarin vs. Other VTE prophylactic agents was evaluated on 30-day deep vein thrombosis (DVT) (OR 1.53, 95% CI 1.39-1.67, p=<0.05). Warfarin was associated with the highest risk for 30-day and 90-day postoperative complications following total hip arthroplasty, including an increased risk of 30-day DVT (OR 1.53).
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