Tubulysins are potent cytotoxic natural tetrapeptides that have attracted great interest as potential drug payloads coupled with monoclonal antibodies for the targeting of tumors. Five years after the publication of their isolation from myxobacteria species, tubulysins (shown) remain a challenge for total synthesis efforts, as published reports of synthesized tubulysin have yet to appear.
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Neri et al. (2006) studied this question.
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