Key result
In young patients with STEMI, the presence of carotid plaque was associated with 3.7 times increased odds for aspirin resistance (P=0.012).
Why the study?
Is there an association between aspirin resistance and high-risk carotid imaging findings in young patients with STEMI?
Cross-Sectional (n=112)
Is there an association between aspirin resistance and high-risk carotid imaging findings in young patients with STEMI?
In young patients with STEMI, the presence of carotid plaque and thicker carotid intima-media thickness are significantly associated with aspirin resistance.
Answers are grounded in this paper and cite their sources.
Carotid plaque may flag aspirin resistance risk in young STEMI; hypothesis-generating association requires prospective confirmation before guiding therapy.
The presence of carotid atherosclerosis accompanied by coronary artery disease is associated with poor prognosis. A subset of patients who take aspirin continue to have recurrent cardiovascular events, which may be due to aspirin resistance (AR). Also, carotid plaques may cause turbulent flow which in turn may lead to platelet activation and poor antiplatelet response. In our study, we aimed to show the prevalence of AR and its relationship between high-risk carotid images in young patients with ST-segment elevated myocardial infarction (STEMI). In our study, we included 112 patients younger than 45 years with STEMI. Aspirin response test was evaluated 1 hour after aspirin intake using multiplate platelet function analyzer, and carotid ultrasonography has been performed to determine carotid intima-media thickness (CIMT) and the presence of carotid plaque. We identified 30.3% AR in young patients with STEMI. Carotid intima-media thickness ( P = .002), carotid plaque ( P = .012), and high-risk carotid image ( P = .015) values are significantly high in patients who have AR. Independent of other risk factors, the presence of carotid plaque and being in the high-risk carotid group were associated with 3.7 times and 3.2 times increased odds for AR, respectively. In young patients with STEMI, physicians should be careful about AR, especially in patients who have carotid plaque and thicker CIMT.
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Somuncu et al. (2018) conducted a cross-sectional in ST-segment elevated myocardial infarction (STEMI) (n=112). Carotid plaque vs. Absence of carotid plaque was evaluated on Aspirin resistance (OR 3.7, p=0.012). In young patients with STEMI, the presence of carotid plaque was associated with 3.7 times increased odds for aspirin resistance (P=0.012).
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