Why the study?
Does FGF10 promote cardiomyocyte proliferation and cell-cycle re-entry in foetal and adult mice?
Population
Fgf10(-/-) mice, primary cardiomyocyte cultures, and adult mice
Comparison
Fgf10 knockout and in vivo overexpression of Fgf10 vs Wild-type/control mice
Design
Preclinical
Key result
FGF10 regulates regional cardiomyocyte proliferation in the foetal heart through a FOXO3/p27(kip1) pathway and triggers cell-cycle re-entry in adult cardiomyocytes.
Authors
Loading...
FGF10 merits testing as a regenerative target in mammalian models; leaves open translation to human cardiac repair.
Does FGF10 promote cardiomyocyte proliferation and cell-cycle re-entry in foetal and adult mice?
FGF10 promotes regional foetal cardiomyocyte proliferation and triggers cell-cycle re-entry in adult cardiomyocytes, highlighting it as a potential target for cardiac regeneration.
Rochais et al. (2014) studied Cardiomyocyte proliferation. FGF10 knockout and overexpression vs. Wild-type/control was evaluated on Cardiomyocyte proliferation and cell-cycle re-entry. FGF10 regulates regional cardiomyocyte proliferation in the foetal heart through a FOXO3/p27(kip1) pathway and triggers cell-cycle re-entry in adult cardiomyocytes.