January 17, 1995Proceedings of the National Academy of SciencesOpen Access

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

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Population

Chicken embryonic model (in vivo cardiac myocytes)

Design

Preclinical

Authors

TMTatsuya MimaRitsumeikan University HUHiroo UenoKyoto University DFDonald A. FischmanCornell University

Discussion

Member takes

Implication

FGF dependence is stage-specific in chick cardiogenesis; leaves open relevance to mammalian models or human congenital heart disease.

Structured PICO

Population

Chicken embryonic model (in vivo cardiac myocytes)

Intervention

Retroviral vectors suppressing FGFR functions (dominant-negative mutant of FGFR1 or antisense RNA against endogenous FGFR1) or overexpressing full-length FGFR1

Outcome

Myocyte proliferation and/or survival during embryonic developmentsurrogate

Receptor-coupled FGF signaling regulates cardiac myocyte growth during early tubular stages of cardiogenesis, but growth becomes FGF-independent after the second week of embryogenesis.

Cite This Study

Mima et al. (1995) studied this question.

synapsesocial.com/papers/6a89a8385c4c6b099dec7ae5 https://doi.org/10.1073/pnas.92.2.467

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Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider