Key result
Following surgical closure of ventricular septal defect, pre-existing moderate or severe pulmonary vascular disease was associated with abnormally low cardiac output and high mortality (5 of 8 died).
Why the study?
Does pre-existing pulmonary vascular disease severity affect postoperative hemodynamics and survival following surgical closure of ventricular septal defect?
Population
16 patients undergoing surgical closure of ventricular septal defect
Comparison
Surgical closure of ventricular septal defect vs Patients with absent or mild pulmonary vascular…
Design
Cohort
Follow-up
3 days
Authors
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May warrant caution before VSD closure in moderate-severe PVD; leaves open prospective validation of risk thresholds.
Observational (n=16)
Does pre-existing pulmonary vascular disease severity affect postoperative hemodynamics and survival following surgical closure of ventricular septal defect?
Pre-existing moderate or severe pulmonary vascular disease is associated with low postoperative cardiac output and high mortality following surgical closure of ventricular septal defect.
Theye et al. (1963) conducted an observational in Ventricular septal defect (n=16). Moderate or severe pulmonary vascular disease vs. Absent or mild pulmonary vascular disease was evaluated on Cardiac output and survival. Following surgical closure of ventricular septal defect, pre-existing moderate or severe pulmonary vascular disease was associated with abnormally low cardiac output and high mortality (5 of 8 died).
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