Key result
Ibuprofen is the drug of choice for pharmacological closure of patent ductus arteriosus in very preterm newborns due to its better safety profile compared to indomethacin.
Why the study?
Persistence of patent ductus arteriosus in very preterm infants increases morbidity and mortality, but the optimal management strategy remains controversial.
Design
Review
Authors
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Short-term benefits of PDA prophylaxis in preterm infants warrant caution in routine use; leaves open long-term outcome effects.
Expectant management of PDA in very preterm infants is gaining interest as a safe alternative to active intervention, while conservative fluid restriction is not routinely recommended due to adverse effects.
Potsiurko et al. (2020) conducted a review in Patent ductus arteriosus. Pharmacological and conservative management of patent ductus arteriosus was evaluated. Ibuprofen is the drug of choice for pharmacological closure of patent ductus arteriosus in very preterm newborns due to its better safety profile compared to indomethacin.
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