Key result
Abelmoschus esculentus alleviated obesity-related metabolic dysfunction in rats via AMPK-mediated activation of brown adipose tissue and white adipose browning.
Why the study?
Abelmoschus esculentus was reported to improve metabolic disorders, but its therapeutic mechanism remained unclear.
Does Abelmoschus esculentus improve obesity-related metabolic disorders in high-fat diet rats?
Does Abelmoschus esculentus improve obesity-related metabolic disorders in high-fat diet rats?
Abelmoschus esculentus alleviates obesity-related metabolic dysfunction via AMPK-mediated activation of BAT and WAT browning in preclinical models.
AE effects on rat BAT/WAT may aid metabolic research; leaves open any human obesity application.
Obesity is a global health concern with high metabolic disease risk. Boosting the activity of brown adipose tissue (BAT) and white adipose tissue (WAT) browning combats against metabolic disorders. Abelmoschus esculentus (AE) was reported to improve metabolic disorders, but the mechanism remains unclear. This study aims to investigate AE's therapeutic mechanism in metabolic disorders. We explore the effect of AE on rats with high-fat diet and the primary adipocytes isolated from rat adipose tissue. In rats, the results showed that AE effectively ameliorated metabolic disorders induced by HFD, enhanced BAT activity, and WAT browning. In addition, AE significantly increased the AMPK phosphorylation in rat adipose tissues and primary adipocytes. Inhibition of AMPK in primary adipocytes abolished AE's beneficial effects, whereas AMPK activation significantly potentiated AE's effect. It demonstrates AE alleviates obesity-related metabolic dysfunction via AMPK-mediated activation of BAT and WAT browning, suggesting AE's therapeutic potential for metabolic disorders management. • AE can improve obesity, insulin resistance, hyperlipoidemia, and increase adaptive thermogenesis in rats. • AE promotes BAT activity and WAT browning in rats and primary adipocytes from rats. • AE may exhibit effects through AMPK-dependent mechanism.
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Gou et al. (2025) studied Obesity-related metabolic disorders. Abelmoschus esculentus (AE) was evaluated on Metabolic disorders, BAT activity, WAT browning, and AMPK phosphorylation. Abelmoschus esculentus alleviated obesity-related metabolic dysfunction in rats via AMPK-mediated activation of brown adipose tissue and white adipose browning.
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