Key result
Intramuscular administration of Marek's disease vaccine provided better protection than subcutaneous administration, with a 4-fold difference in PD50 estimates.
Why the study?
Does intramuscular administration of Marek's disease vaccine improve protection compared to subcutaneous administration in SPF chickens?
Population
Specific-pathogen-free (SPF) chickens (female in trials 1 and 2, both sexes in trials 3 and 4)
Comparison
Intramuscular inoculation of cell-associated… vs Subcutaneous inoculation of the same vaccine
Design
Preclinical
Authors
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May inform route optimization in avian vaccine studies; leaves open translation to commercial poultry dosing.
Does intramuscular administration of Marek's disease vaccine improve protection compared to subcutaneous administration in SPF chickens?
Intramuscular administration of Marek's disease vaccine provides better protection than subcutaneous administration in chickens, suggesting a need to increase the field dose if the subcutaneous route is used.
Oei et al. (1986) studied Marek's disease. Intramuscular administration of Marek's disease vaccine vs. Subcutaneous administration was evaluated on 50% protective dose (PD50). Intramuscular administration of Marek's disease vaccine provided better protection than subcutaneous administration, with a 4-fold difference in PD50 estimates.
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