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Mycelia ofPhytophthora cactorum, a fungus unable to synthesize sterols, were incubated with a series of sterols and several common sterol solubilizing agents. Cholesterol, campesterol, and sitosterol promoted growth, while carpesterol, saringosterol, 20 α‐hydroxy cholesterol, coprostanol, and 5α‐cholestane inhibited growth. Cholestanol, epicholestanol, and 5α‐cholestan‐3‐one had no significant effect on growth relative to the sterol‐free control. All steroids were solubilized in ethanol for studying structure‐activity correlations. The added steroids were reisolated from mycelia and their identity confirmed by gas liquid chromatography (GLC) or combined gas liquid chromatography‐mass spectrometry (GLC‐MS). Tween 80 promoted growth, Triton X‐100 inhibited growth, and ethanol had no effect on growth relative to a control.
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Nes et al. (1979) studied this question.
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