Key result
Serum neurofilament light in atrial fibrillation patients was associated with the CHA2DS2-VASc score (19.2% increase per unit; 95% CI 17.2-21.3%), vascular brain lesions, and cognitive function.
Why the study?
AF is associated with cognitive dysfunction independently of stroke, but the underlying mechanisms remain unclear.
Population
1379 AF patients in the Swiss-AF Study
Comparison
Associations with serum neurofilament light protein levels
Design
Cross-sectional analysis
Authors
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Serum NfL was associated with CHA2DS2-VASc in AF; leaves open its role in stroke-independent cognitive decline.
Cross-Sectional (n=1,379)
Effect estimate: 19.2% increase per unit (95% CI 17.2-21.3)
In patients with atrial fibrillation, serum neurofilament light protein correlates with clinical risk factors, vascular brain lesions, and cognitive dysfunction, suggesting its utility as a biomarker for neuronal injury.
Polymeris et al. (2020) conducted a cross-sectional in Atrial fibrillation (n=1,379). Serum neurofilament light protein was evaluated on Association with CHA2DS2-VASc score (19.2% increase per unit, 95% CI 17.2-21.3). Serum neurofilament light in atrial fibrillation patients was associated with the CHA2DS2-VASc score (19.2% increase per unit; 95% CI 17.2-21.3%), vascular brain lesions, and cognitive function.
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